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Case Study

Uptiv Health: Putting AI Agents to Work in Infusion Care at a Fast-Growing Provider Group

Launching agentic referral operations on the Skypoint AI application suite for provider groups.
  • skyReferral™ went live in production — AI agents read inbound referral faxes, structure the data, and send confirmations end-to-end. Real work executed by AI, not suggestions for a human to action later.
  • Incoming faxes processed and referrals actively managed by the second business day of go-live — with benefits verification and prior authorization (BV/PA) as the next phase.
FOCUS

Modern infusion therapy for chronic & complex conditions (MS, Crohn’s, ulcerative colitis, rheumatoid arthritis)

FOUNDED

2023 · Headquartered in Westland, Michigan

LEADERSHIP

Torben Nielsen, CEO · Marina Simonian, Head of Product

PLATFORM

Uptiv ONE, powered by the Skypoint AI Platform — skyReferral™ & skyAgent™

uptiv-health-portrait

Founded in 2023, Uptiv Health set out to reinvent one of healthcare’s most burdensome experiences: infusion therapy for people living with chronic and complex conditions. Its model pairs retail-style infusion suites with a patient-centric app and whole-person care — “where clinical infusion meets modern comfort and whole-person care.” But delivering that experience at scale depends on something patients never see: fast, accurate, high-volume back-office operations that get a patient from referral to first infusion without delay.

To run those operations, Uptiv is building Uptiv ONE — its operating platform — on the Skypoint AI Platform. The goal was not another analytics dashboard. Uptiv wanted AI agents that actually do the work, embedded directly in the referral and access workflows that determine speed-to-therapy. In June 2026, the first of those agents went live.

“Congratulations, Marina and team, for a great step forward for Uptiv Health. This is a major milestone! Best of all — Uptiv ONE is still in its early beginnings, and I can’t wait to see it evolve over the next months and years.”

Torben Nielsen

  • CEO, Uptiv Health

The administrative drag on infusion access

Infusion therapy sits at the intersection of high drug costs, complex payer rules, and time-sensitive patient need — which makes its intake process unusually heavy. Referrals still arrive largely by fax. Each one has to be read, validated, matched to a patient, and acknowledged. Before therapy can begin, staff must verify benefits and secure prior authorization, a manual, payer-by-payer slog that is the single biggest source of delay and abandoned referrals in specialty care.

Every hour spent keying fax data, chasing missing fields, or re-checking eligibility is an hour not spent on patients — and every day of delay is a patient waiting longer for treatment and a referral at risk of leaking to another provider. For a fast-growing infusion company, that administrative drag is a hard ceiling on growth. Uptiv needed to lift it without simply hiring more coordinators.

"The Skypoint team has done an amazing job with a very fast-paced dev cycle. This is coming together very nicely to be the next best-in-class infusion optimization platform."

Marina Simonian

  • Head of Product, Uptiv Health

Why agentic AI — not another dashboard

Skypoint takes a deliberately different stance from traditional healthcare analytics: AI agents that execute real work across the patient journey, embedded in existing EHR and operational workflows, rather than dashboards that surface insights for someone else to act on. The same approach powers a broad suite of agentic applications and integrations across revenue cycle, front office, and care operations.

 

Under the hood, those agents run on skyAgent™ (agentic harness), Skypoint’s autonomous agent system built on Google Vertex, Anthropic’s Claude and Google Gemini models. A central reasoning engine orchestrates specialized sub-agents and tools, governed by a persistent agent harness that handles long-running workflows, state, auditability, and exception handling — the operational backbone regulated healthcare requires. The platform is HITRUST r2 and SOC 2 Type 2 certified, with role-based access control and row-level security on every data query.

 

For Uptiv, the first agent in production is skyReferral™ — which automates referral intake and follow-up to reduce patient leakage and speed coordination. Crucially, Skypoint didn’t deliver it from a distance. Forward-deployed engineers worked alongside Uptiv’s team and partner Coral Connect through a fast-paced development cycle, building and tuning the agents to Uptiv’s real fax formats, payers, and workflows — delivering a working go-live in weeks, not months.

Go-live: skyReferral™ in production

Uptiv launched skyReferral™ on Friday, June 12, 2026 — a deliberately light day chosen to de-risk the rollout. On day one, the agents processed inbound faxes, identified the referrals among them, and after a review and approval from an RCM specialist, sent a confirmation fax for each. A shared support bridge stayed open with the Uptiv, Skypoint, and Coral teams; the few minor snags that surfaced were addressed within minutes, and the system was ready for full volume on Monday.

By Monday, June 15, throughput had roughly doubled — with more faxes processed and more active referrals being worked through skyReferral™. With telemetry monitoring exceptions and a war-room channel in place, the team was confident enough to begin shifting from an always-on support bridge to as-needed support — a sign that the agents were doing the work reliably, not just demonstrably.

Go-live snapshot

100%

Inbound faxes processed by AI agents across the first two business days

100%

New referrals being worked through skyReferral™ by Day 2

100%

Referrals acknowledged with a confirmation fax

Weeks

From kick off to production go-live, via forward-deployed engineering

Figures reflect the first two business days of the skyReferral™ go-live (June 12 & 15, 2026).

What’s next: BV/PA and the infusion optimization platform

Referral intake is the first workflow, not the destination. The roadmap moves next to benefits verification and prior authorization (BV/PA) — the highest-friction, highest-value step in infusion access — using Skypoint’s skyAuth™ agents to verify coverage and secure authorizations faster, with less manual burden. From there, Uptiv plans to extend the platform toward a broader infusion optimization platform, co-developed on the same Skypoint foundation.

Because skyAgent™ is configuration-driven and built on an open, MCP-based architecture, new agents, tools, and workflows can be added without re-platforming — and Uptiv’s team can co-develop on the platform directly. The result is a system that compounds: every workflow Uptiv automates makes the next one faster to stand up.

Where clinical infusion meets agentic AI

Uptiv Health set out to make infusion care more human. Doing that at scale meant removing the administrative drag that slows patients down before treatment ever begins. With skyReferral™ live and BV/PA on the way, Uptiv now has AI agents doing real operational work — reading faxes, structuring referrals, sending confirmations, and clearing the path to therapy — on a HITRUST-certified platform built to grow with them. It is, as the team put it, still in its early beginnings.

“We processed a batch of faxes, several of which were referrals, and sent confirmation faxes for each. We hit a few minor snags that were addressed very quickly — and the team is ready to process more come Monday.”

Marina Simonian

  • Head of Product, Uptiv Health — go-live update, June 12, 2026

Put AI agents to work in your practice

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